Upton ⁎ Australian Centre for Pharmacometrics and Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, SA 5000, AustraliaĪrticle history: Received 30 October 2014 Received in revised form 25 March 2015 Accepted 27 March 2015 Available online 2 April 2015 Keywords: ADVAN Analytical solutions Intravenous Methods Modelling NONMEM Oral Pharmacokinetics R-language SimulationsĪ b s t r a c t Introduction: The analytical solutions to compartmental pharmacokinetic models are well known, but have not been presented in a form that easily allows for complex dosing regimen and changes in covariate/parameter values that may occur at discrete times within and/or between dosing intervals. Journal of Pharmacological and Toxicological Methods journal homepage: Original articleĪDVAN-style analytical solutions for common pharmacokinetic models Ahmad Y. Journal of Pharmacological and Toxicological Methods 73 (2015) 42–48Ĭontents lists available at ScienceDirect
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